An update on the use of sedative-hypnotic medications in psychiatric disorders. Antidepressants, anxiolytics, and hypnotics in pregnancy and lactation. However, there are several side effects and risks. Trazodone is considered a non-addictive SSRI antidepressant used to treat depression, anxiety and insomnia. Unintentional trazodone overdoses in children ≤6 years of age: data from poison center over a period of 16 years. With outpatient and residential programs throughout the country, we offer every patient the best chance of lifelong recovery. Antidepressants and cardiovascular adverse events: A narrative review. Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: An American Academy of Sleep Medicine clinical practice guideline. Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL. ![]() On the lower doses I had no side effects after the initial break-in period. Initially this medication worked like a charm, in terms of getting to sleep and staying asleep for 7-8 hours. Therapy with trazodone should be administered cautiously in patients with hypotension or conditions that could be exacerbated by hypotension, such as a history of myocardial infarction, angina, or. I initially started on 25 mg and now am on 125 mg (taken right before bed for insomnia). Histamine in the regulation of wakefulness. Trazodone has alpha-1 adrenergic blocking activity and may cause hypotension (including orthostatic hypotension) in approximately 5 of patients. Rediscovering trazodone for the treatment of major depressive disorder. Trazodone for insomnia: a systematic review. Given its unique mechanism of action, bupropion may be the most appropriate antidepressant for older adults at risk for antidepressant-induced hyponatremia.Jaffer KY, Chang T, Vanle B, et al. Bupropion, trazodone, and tricyclic antidepressants were implicated less often in the same literature. Selective serotonin reuptake inhibitors, serotonin/norepinephrine reuptake inhibitors, and mirtazapine were implicated in the majority of the case reports and clinical studies evaluating older adults. ![]() Hyponatremia was counted as an adverse effect if an antidepressant was the likely cause of hyponatremia, and hyponatremia was resolved after withdrawal.Īntidepressant-induced hyponatremia in older adults is fairly common. ![]() Publications were chosen based on relevance to the review: case reports of patients 60 years of age or older or clinical investigations of the association between hyponatremia and antidepressants in older adults. Out of 363 results, 124 publications were identified and reviewed along with 11 additional references. As an atypical antidepressant, trazodone does not fit neatly into some of the more standard antidepressant classes (e.g., SSRIs, MAOIs, tricyclic antidepressants, etc.). A search of product labeling was also conducted. Trazodone is an antidepressant primarily indicated for use in treating major depressive disorder but perhaps more commonly used off-label for managing insomnia. Search terms included: antidepressive agents, antidepressive agents second-generation, bupropion, citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine, fluvoxamine, hyponatremia, milnacipran, mirtazapine, paroxetine, reboxetine, syndrome of inappropriate antidiuretic hormone, sertraline, trazodone, venlafaxine, and vilazodone. To describe the prevalence of hyponatremia in older adults related to antidepressive agents and identify potential alternative options in older adults with a low-baseline serum sodium concentration and/or when a patient has experienced hyponatremia as a result of taking an antidepressant.Ī PubMed search was conducted on November 10, 2015.
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